Biology student outcomes assessed in the 2012-2013 academic year concentrated on early curricular outcomes that focused on key skills and abilities referred to as Mastery Skills. Assessment this year focused on Mastery Skills of three core-biology courses. Two of those courses are a foundational course sequence in Human Anatomy and Physiology (BIO 167 & 168) that are core-courses in the Human Biology Program. The other course was Cell Biology (BIO 326) a sophomore/junior–level course that is common to all of our undergraduate programs. Our assessment this year revealed that BIO 167/168 students attain good to excellent mastery of a wide range of learning objectives in the topic area of homeostasis, an overarching principle of human physiology and biology in general. As expected, the lowest level of student mastery involved higher cognitive level learning outcomes (e.g. synthesis questions related to disturbances of homeostasis). Still, students met our goal for mastery of these learning objectives in introductory courses that provide a foundation for future learning. Our assessment of BIO 326 focused on a general assessment of a range of learning outcomes using a new pre-test/post-test assessment tool. This assessment revealed that students on average mastered a wide range of cell biology learning objectives. The department plans to refine this assessment tool to better identify specific learning objectives where students have the most difficulty.