| Office: | 2205 WSW |
| Phone: | 810.237.6503 |
| E-mail: | dgordon@umflint.edu |
| Web Site: | www.umflint.edu/shps/ |
| Mar. 1, 1985- July 1, 1991 | Assistant Professor of Pathology, Department of Pathology, University of Washington School of Medicine, Seattle, WA |
| July 1, 1991- Nov. 15, 1991 | Associate Professor of Pathology (with tenure), Department of Pathology, University of Washington School of Medicine, Seattle, WA |
| Dec. 1, 1991- Nov. 16, 1997 | Associate Professor of Pathology, Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI (Received tenure 1997) |
| Nov. 16, 1997- Jan. 31, 2001 | Adjunct Associate Professor of Pathology, Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI (Note: during this time I was a research fellow with Pfizer Global Research and Development, Ann Arbor, MI.)> |
| Feb. 1, 2001- present | Professor of Pathology (with tenure), Dept. of Pathology, Univ. of Michigan School of Medicine, Ann Arbor, MI |
| Mar. 1, 1985- Nov. 15, 1991 | Director of Autopsy Service, Univ. of Washington, Univ. Hospital |
| Aug. 1, 1994- Nov. 16, 1997 | Assistant Dean for Faculty Affairs, University of Michigan, Ann Arbor, MI. |
| July 1, 1996- Nov. 16, 1997 | Associate Director, Jobst Vascular Research Laboratory, Div. of Vascular Surgery, University of Michigan, Ann Arbor, MI |
| Feb. 1, 2001- Mar. 31, 2004 | Assistant Dean for Diversity and Career Development. University of Michigan, Ann Arbor, MI |
| April 1, 2004- 2011 | Associate Dean for Diversity and Career Development, University of Michigan, Ann Arbor, MI |
| Aug. 16, 2011- Present | Dean, School of Health Professions and Studies, University of Michigan-Flint, Flint, MI |
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Rekhter MD, Gordon D: Active proliferation of different cell types, including lymphocytes in human atherosclerotic plaques. Am. J. Pathol; 147:668-677, 1995.
Kolpakov V, Gordon D, Kulik TJ: Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circ. Res; 76:305-309, 1995.
Pompili VJ, Gordon D, San H, Yang Z, Muller DWM, Nabel GJ, Nabel EG: Expression and function of a recombinant PDGF B gene in porcine arteries. Arterioscler. Thromb. Vasc. Biol; 15:2254-2264, 1995.
Kolpakov V, Rekhter MD, Gordon D, Wang WH, Kulik TJ: Effect of mechanical force on growth and matrix protein synthesis in the in vitro pulmonary artery: Analysis of the role of individual cell types. Circ Res; 77:823-831, 1995.
Thackray BD, Burns DH, Fergurson MS, Gordon D, Beach KW, Hatsukami T, Detmer PR, Primozich JF, Strandness DE. A new method of studying plaque morphology. Amer. J. of Cardiac Imaging; 9:149-156, 1995.
Kang S, Kim KJ, Griffiths CEM, Wong TY, Talwar HS, Fisher GJ, Gordon D, Hamilton TA, Ellis CN, Voorhees JJ. Topical tretinoin (retinoic acid) improves early stretch marks. Arch Dermatol; 132:519-526, 1996.
Schwartz SM, Gordon D, Mosca RS, Bove EL, Heidelberger KP, Kulik TJ. Collagen content in normal, pressure and pressure-volume overloaded developing human hearts. Am J Cardiol; 77:734-738, 1996.
Simari RD, San H, Rekhter M, Ohno T, Gordon D, Nabel GJ, Nabel EG. Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries. J Clin Invest; 98:225-235, 1996.
Yang ZY, Simari RD, Perkins ND, San H, Gordon D, Nabel GJ, Nabel EG. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc Natl Acad Sci USA; 93:7905-7910, 1996.
Sarkar R, Meinberg EG, Stanley JC, Gordon D, Webb RC. Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circ Res; 78:225-230, 1996.
Rekhter M, Nicholls S, Ferguson M, Gordon D. Cell proliferation in human arteriovenous fistulas used for hemodialysis. Arteriosclerosis and Thrombosis; 13:609-617, 1996.
Nabel GJ, Yang ZY, Nabel EG, Bishop K, Marquet M, Felgner PL, Gordon D, Chang AE. Direct gene transfer for treatment of human cancer. Ann. N.Y. Acad. Sci; 772:227-31, 1996
Chang MW, Ohno T, Gordon D, Lu MM, Nabel GJ, Nabel EG, Leiden JM. Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid artery. Mol. Med; 1(2):172-81, 1996.
Fox BA, Woffendin C, Yang ZY, San H, Ranga U, Gordon D, Osterholzer J, Nabel GJ: Genetic modification of human peripheral blood lymphocytes with a transdominant negative form of Rev: safety and toxicity. Hum. Gene Ther; 6(8):997-1004, 1995.
Rekhter MD, O'Brien E, Shah N, Schwartz SM, Si mpson JB, Gordon D: The importance of thrombus organization and stellate cell phenotype in collagen I gene expression in human, coronary atherosclerotic and restenotic lesions. Cardiovascular Research; 32:496-502, 1996.
Nabel GJ, Gordon D, Bishop DK, Nickoloff BJ, Yang ZY, Aruga A, Cameron MJ, Nabel EG, Chang AE. Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes. Proc Natl Acad Sci USA; 93:15388-15393, 1996.
DeBruyne LA, Chang AE, Cameron MJ, Yang Z, Gordon D, Nabel EG, Nabel GJ, Bishop DK. Direct transfer of a foreign MHC gene into human melanoma alters T cell receptor V beta usage by tumor-infiltrating lymphocytes. Cancer Immunol. Immunother; 43(1): 49-58, 1996.
Welling TH, Davidson BL, Zelenock JA, Stanley JC, Gordon D, Roessler BJ, Messina LM. Systemic delivery of the interleukin-1 receptor antagonist protein using a new strategy of direct adenoviral-mediated gene transfer to skeletal muscle capillary endothelium in the isolated rat hindlimb. Hum. Gene Ther; 7(15):1795-802, 1996.
Stephan DJ, Yang ZY, San H, Simari RD, Wheeler CJ, Felgner PL, Gordon D, Nabel GJ, Nabel EG. A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo. Hum. Gene Ther; 7(15):1803-12, 1996.
Isik FF, Coughlin SR, Nelken NA, Clowes AW, Gordon D. JE gene expression in an animal model of acute arterial graft rejection. J. Surg. Res; 60(1):224-31, 1996.
Muller DW, Gordon D, Topol EJ, Levy RJ, Golomb G. Sustained-release local hirulog therapy decreases early thrombosis but not neointimal thickening after arterial stenting. Am. Heart J; 131(2):211-8, 1996.
Sarkar R, Gordon D, Stanley JC, Web RC. Cell cycle effects of nitric oxide on vascular smooth muscle cells. Am. J. Physiol. 272:10050-10057, 1997.
Sarkar R, Gordon D, Stanley JC, Webb RC. Dual cell cycle-specific mechanisms mediate the antimitogenic effects of nitric oxide in vascular smooth muscle cells. J. Hypertens; 15(3):275-283, 1997.
Arai H, Gordon D, Nabel EG, Nabel GJ. Gene transfer of Fas ligand induces tumor regression in vivo. Proc. Natl. Acad. Sci. USA; 94(25):13862-7, 1997.
Stephan D, San H, Gordon D, Nabel GJ, Nabel EG. [Gene transfer of interferon beta inhibits vascular smooth muscle cell proliferation in vitro and in animal model of arterial injury.] Arch. Mal. Coeur. Vaiss; 90(8):1121-5, 1997.
Stephan D, San H, Yang ZY, Gordon D, Goelz S, Nabel GJ, Nabel EG. Inhibition of vascular smooth muscle cell proliferation and intimal hyperplasia by gene transfer of beta-interferon. Mol. Med; 3(9):593-9, 1997.
Lin H, Gastman BR, Wei RQ, Kunkel SL, Gordon D, Bolling SF. Phase-directed therapy and cardiac xenograft survival. J. Surg. Res; 72(1):84-8, 1997.
Jejurikar SS, Welling TH, Zelenock JA, Gordon D, Burkel WE, Carlson BM, Messina LM. Induction of angiogenesis by lidocaine and basic fibroblast growth factor: a model for in vivo retroviral-mediated gene therapy. J. Surg. Res; 67(2):137-46, 1997.
Hatsukami TS, Ferguson MS, Beach KW, Gordon D, Detmer P, Burns D, Alpers C, Strandness DE Jr. Carotid plaque morphology and clinical events. Stroke; 28(1):95-100, 1997.
Lupinetti-FM; Kneebone JM, Rekhter MD, Brockbank KG, Gordon D. Procollagen production in fresh and cryopreserved aortic valve grafts. J. Thorac. Cardiovasc. Surg; 113(1):102-7, 1997.
Tanner FC, Yang Z, Duckers E, Gordon D , Nabel GJ, Nabel EG: Expression of cyclin-dependent kinase inhibitors in vascular disease. Circ. Res. 82:396-403, 1998.
Rekhter MD, Simari RD, Work C, Nabel EG, Gordon D. Gene transfer into normal and atherosclerotic human blood vessels. Circ Res; 82:1243-1252, 1998.
Rekhter MD, Shah N, Simari RD, Work C, Kim J-S, Nabel GJ, Gordon D. Graft permeabilization facilitates gene therapy of transplant arteriosclerosis in rabbit model. Circulation; 98(13): 1335-41, 1998.
Rekhter MD, Hicks GW, Brammer DW, Work CW, Kim JS, Gordon D, Keiser JA, Ryan MJ: Animal model that mimics atherosclerotic plaque rupture. Circ Res, 83(7): 705-13, 1998.
Orekhov AN, Andreeva ER, Mikhailova IA, Gordon D: Cell proliferation in normal and atherosclerotic human aorta: proliferative splash in lipid-rich lesions. Atherosclerosis; Jul; 139(1): 41-8, 1998.
Andreeva ER, Pugach IM, Gordon D, Orekhov AN: Continuous subendothelial network formed by pericyte-like cells in human vascular bed. Tissue and Cell; Feb; 30(1): 127-35, 1998.
Ryan, MJ, Emig LL, Hicks GW, Ramharack R, Brammer DW, Gordon D, Auerbach BJ, Keiser JA: Influence of lipoprotein(a) plasma concentration on neointimal growth in a monkey model of vascular injury. Atherosclerosis 139:137-145, 1999.
Kornowski R, Leon MB, Fuchs S, Vodovotz Y, Flynn MA, Gordon D, Pierre A, Kovesdi I, Keiser JA, Epstein SE: Electromagnetic-guidance for catheter-based trans-endocardial injection: a platform for intramyocardial angiogenesis therapy. J. Am. Coll. Cardiol. 35(4):1031-1039, 2000.
Flynn MA, Vodovotz Y, Kornowski R, Epstein S, Gordon D, Keiser JA: Use of fluorescent microspheres to localize in vivo gene transfer injection sites. BioTechniques, 28(3):470-476, 2000.
Song Y, Ford JW, Gordon D, Shanley CJ: Regulation of lysyl oxidase by interferon- in rat aortic smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 20: 982-988, 2000.
Sjöland H, Eitzman DT, Gordon D, Westrick R, Nabel EG, Ginsburg D: Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arterioscler. Thromb. Vasc. Biol; 20(3):846-52, 2000.
Wang H, Gordon D, Olszewski B, Song YL, Kovesdi I, Keiser JA: Rat sponge implant model: A new system for evaluating angiogenic gene transfer. Int. J. Mol. Med; 6(6):645-653, 2000.
Wang H. Liu C. Song Y. Gordon D. Alavi MZ. Moore S: Expression of metalloproteinases and its inhibitor in later stage of rabbit neointima development. International Journal of Molecular Medicine. 7(1):105-12, 2001
Perrin LA, June JE, Rosebury W, Robertson A, Kovesdi I, Bruder JT, Kessler PD, Keiser, JA, Gordon D: Increased revascularization efficacy after administration of an adenovirus encoding VEGF121. Gene Therapy 11:512-521, 2004.
Wang H, Keiser JA, Olszewski B, Brammer D, Gordon D: Dose-dependent neovascularization-promoting effect of adenovirus vector CI-1023 in a rat hindlimb ischaemic model. Basic & Clinical Pharmacology & Toxicology. 95(2):76-80, 2004 Aug
Wang H. Keiser JA. Olszewski B. Rosebury W. Robertson A. Kovesdi I. Gordon D: Delayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF. International Journal of Molecular Medicine. 13(4):581-7, 2004 Apr.
Miller DL, Li P, Gordon D, Armstrong, WF: Histological characterization of micro-lesions induced by myocardial contrast echocardiography. Echocardiography 22(1):25-34, 2005.
Miller DL, Li P., Dou C., Gordon D., Edwards C. A. and Armstrong, W. F.: Influence of Contrast Agent Dose and Ultrasound Exposure on Cardiomyocyte Injury Induced by Myocardial Contrast Echocardiography in Rats. Radiology 2005;237:137-143
Shen Y, Bodary PF, Vargas FB, Homeister JW, Gordon D, Ostenso KA, Shayman JA, and Eitzman DT: -Galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the Factor V Leiden mutation.” Stroke 2006 37: 1106 – 1108
Miller DL, Li P, Dou C, Armstrong WF, Gordon D. Evans blue staining of cardiomyocytes induced by myocardial contrast echocardiography in rats: evidence for necrosis instead of apoptosis. Ultrasound Med Biol. 2007; 33(12):1988-96.
Gualano SK. Bolling SF. Gordon D. Wilson A. Bach DS.: High prevalence of false chordae tendinae in patients without left ventricular tachycardia. Pacing & Clinical Electrophysiology, 2007, Suppl. 30, 1:S156-159
Hoashi T, Florentine MS, Gordon D, Ohye RG: Cardiac papillary fibroelastoma presenting as chorea in childhood. Pediatr. Cardiol. 2009;30:995-7
Faust SM. Lu G, Marini BL, Zou W, Gordon D, Iwakura Y, Yasmina Laouar Y, and Bishop DK: Role of T Cell Transforming Growth Factor Beta Signaling and IL-17 in Allograft Acceptancee and Fibrosis Associated with Chronic Rejection" J. Immunol. 2009;183:7297-7306
Xu Z, Owens G, MD, Gordon D, Cain C, Ludomirsky A: Noninvasive creation of an atrial septal defect by histotrypsy in a canine model. Circulation 2010, 121:742-749
Bhavsar J, Gordon D, Shea M: Listeria myocarditis with an atypical intracavitary vegetation/thrombus. Heart 2010, 96:1637. [case report]
Gordon D and Schwartz, SM: “Arterial smooth muscle differentiation”, in: JH Campbell and GR Campbell (eds.). In: Vascular Smooth Muscle in Tissue Culture, 1987.
Wilcox, JN, Schwartz, SM and Gordon D: “Local production of PDGF in the human atherosclerotic plaque”, in: Habenicht, Springer-Verlag and Heidelberg (eds.), In: Growth Factors, Differentiation Factors and Cytokines, 1990.
Gordon D: “Cell proliferation in human arteries”. Cardiovascular Pathology, 1992.
Nabel GJ, Nabel EG, Yang Z, Fox BA, Plautz GE, Gao X, Huang L, Shu S, Gordon D, Chang AE: “Molecular genetic interventions for cancer.” Cold Spring Harbor Symposia on Quantitative Biology. Vol LIX:699-707, 1994.
Gordon D and Rekhter MD. “Cell proliferation and collagen gene expression in human intimal hyperplasia”. In: Dorbin (ed), Intimal Hyperplasia, 1994.
Gordon D and Nable EG: “Growth factors as inducers of neointimal hyperplasia”. In: Orosz, Sedmak and Ferguson (eds.), In: Transplant Vascular Sclerosis, 1995.
Kohler T and Gordon D. “Cerebrovascular atherosclerosis”. In: Zierler (ed), Surgical Management of Cerebrovascular Disease, 1995.
Gordon D. “Human carotid artery atherosclerosis”. In: Ernst and Stanley (eds), Current Therapy in Vascular Surgery, 1995.
Gordon D. “Transplant Arteriosclerosis”. In: Ross and Topol (eds). Atherosclerosis and Coronary Artery Disease, 1996.
Gordon D., Rekhter MD: “The growth of human atherosclerosis: Cell proliferation and collagen synthesis.” Cardiovasc. Pathol. 6:103-116, 1997.
Gordon D, Song Y: “The Pathology of Human Carotid Restenosis.” In Ernst and Stanley (eds), Current Therapy in Vascular Surgery, 1999 in press.
Gordon D. “Transplant Arteriosclerosis” (Ch. 43, pp. 623-635) in Atherothrombosis and coronary Artery Disease ed. Fuster, Topol, and Nabel. Copyright 2005 by Lippincott Williams & Wilkins.